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EBI PSI-BLAST API - Developers

Position Specific Iterative BLAST (PSI-BLAST) constructs a position-specific scoring matrix (PSSM) profile for a protein sequence using a set of BLAST alignments. The PSSM is then used to search the database in subsequent iterations, allowing the detection of distant evolutionary relationships between protein sequences. The PSI-BLAST API is provided by the European Bioinformatics Institute via SOAP and REST protocols.