| API | Description | Category | Date |
|---|---|---|---|
| DKFZ SoapDB | Genetics and protein sequence databases | Science | 2012-02-10 |
| Doctoralia | Medical Doctors and Centers Database | Database | 2012-12-28 |
| Duplicated Genes Database | Database of co-located and duplicated genes | Science | 2012-02-28 |
| Dydra | Cloud-based RDF store | Database | 2011-05-12 |
| e-Fungi | Fungi genomics database and analysis service | Science | 2012-03-08 |
| EBI WSDbfetch | Biological database search service | Science | 2012-02-21 |
| EBI WU-BLAST | Database search for biological sequence similarities | Science | 2012-02-21 |
| EcoSystemData | Biological system data warehouse service | Science | 2012-10-05 |
| Edmunds.com Dealer | Vehicle dealer information | Database | 2011-11-02 |
| Edmunds.com Vehicle | Automobile information | Reference | 2011-11-02 |
| ELMdb | Protein functional site database | Science | 2012-08-17 |
| Ensembl | Multi-species genomic information databases | Science | 2012-11-27 |
| ERCOT MarkeTrak | Texas energy market information service | Database | 2013-01-09 |
| Evrythng | Online profiles for physical objects | Database | 2011-06-08 |
| Facetly | E-commerce product search service | Search | 2012-08-16 |
| Factolex | Fact/Lexicon Database Service | Database | 2010-12-29 |
| Factual | Definitive Global Data. Fast, Rich APIs. | Database | 2009-10-28 |
| Factual Places | Open Data for sharing and reference tools | Mapping | 2011-08-08 |
| FAOdata | Worldwide food and agriculture data | Database | 2012-12-28 |
| FileStorm | File Hosting Service | Storage | 2012-07-27 |
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