phpFlickr is a wrapper that allows developers to easily integrate the Flickr API's functions into their PHP applications. The wrapper covers functions for authentication, caching, uploading photos, and replacing photos.
The popular picture-sharing empire behind I Can Has Cheezburger lets you view, caption and share funny images. You can do this via its sites and, the now, thanks to their API, you can do it via code (technical details at our Cheezburger API profile).
Who ever said that institutions were loathe to change? Well call him up and let him know, the Library of Congress, with their Prints and Photographs API has finally taken the REST API plunge. If this government institution can do it, maybe you can convince the head of your IT department that APIs are a good idea too.