The Golm Metabolome Database (GMD) offers a collection of APIs that provide programmatic access to the GMD's search functions. These APIs allow users to search for metabolites by inputting GC-MS spectral data consisting of a retention index and mass intensity ratios. Metabolites that don't yet have reference mass spectra included in the GMD can be characterized by the predicted presence or absence of functional groups. There is also a search API specific to the GoBioSpace database, which is part of the GMD. The GMD APIs operate over SOAP, GET, and POST protocols.