The service provides access to a database of molecular protein building blocks that recur in different combinations as part of organisms' genetic makeup. The search function helps to uncover associations between chemical elements of genetic structures documented in disparate data sources.
API methods support selection of databases to search and configuration of conserved domains, as defined by NCBI, to match. Methods allow selection of search modes from basic to advanced, with complex Boolean queries, and filtered results. Methods also allow specification of Entrez-based protein designations in search queries.