The ProDom blastpgpProDom API performs a recursive psi-blast from a query, a bank, and an alignment. By default, the psi-blast involves 10 iterations. Developers can use the ProDom fetchProDom API's output as the entry for this API.
ProDom hosts a comprehensive database of protein domain families. These domain families are automatically generated from global comparisons of all available protein sequences in the UniProt Knowledge Database.