The ProDom fetchProDom API provides commands for interrogating the ProDom database. Developers can enter a ProDom AC and get back the family description in either prodom or fasta format, the alignment of the proteins in the ProDom family, the consensus sequence, or the domain composition of the protein. Developers can also enter one or more keywords a get back the ProDom family or families that have the keyword(s) in their description field in prodom format along with a file with only their AC.
ProDom hosts a comprehensive database of protein domain families. These domain families are automatically generated from global comparisons of all available protein sequences in the UniProt Knowledge Database.