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UMLS REST API supports web-based searches and content retrieval at the Unified Medical Language System (UMLS) database operated by the U.S. National Library of Medicine. Updated bi-annually in May and November every year, the UMLS facilitates the management of a wide range of data that includes patients’ demographic characteristics, genealogical data, and other crucial biomedical information. The current release of the UMLS REST is in beta version and its documentation is also available at the API’s homepage. Its access is authenticated through the use of tickets.