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It's always exciting to see those outside the web industry using an API to improve their sites. NY Times First Look blog has a great example of what Dallas Public Library has done with the Best Sellers API.
If you are into developing word games and have been scouting around for both a word database and an API to go with to make things easier, Wordnik may just have delivered the solution for you. The online dictionary's latest version of its Wordnik API is squarely targeting word game developers by giving them additional methods that will help them find words with a great degree of control.