Python FedEx is a lightweight library that wraps the FedEx API. The library's only dependencies are the suds SOAP module and Python 2.5+. The library doesn't yet work with Python 3.0. Python FedEx supports calls for shipment creation, cancellation, and tracking.
Rather than getting caught up in a religious debate about the best method for integrating applications, it's best to accept the fact that depending on the age and the use case of the application, every integration scenario is likely to be different. Recognizing that reality, Informatica this week unfurled its Informatica Cloud Winter 2014 cloud service that, in addition to providing more business process controls, now includes support for RESTful APIs.