This is a multimodel quickstart to access the InterSystems IRIS Native API for Python. It shows object, relational, and native access from a Python application to InterSystems IRIS. It stores Airport data using objects, retrieves data using SQL, and creates custom data structure utilizing the Native API to handle route information between airports. InterSystems IRIS capabilities includes; Hybrid transaction-analytic processing (HTAP) to support real-time applications, Multiple data models, Embedded and open analytics, Natural language processing and more. InterSystems is a global provider of database, integration, and analytics software in healthcare, finance and others.