The Issuu Node.js SDK by Jaroslav Khorishchenko is still a work in progress to access the API. However, it does include methods to upload documents from a list. Installation, initialization, and calls as additional resources.
Service discovery is not an easy task in today's Web. Discovering an API requires searching through a large number of services on the Internet and then reading pages of documentation to figure out how to use the ones that may match your application. This is the case in Programmable Web as well. The API directory shows over 5000 APIs which are manually categorized in over 50 service categories.
Microsoft is one of the first--and certainly the largest of--customers of Wolfram Alpha's commercial API (our Wolfram|Alpha API profile). For math and nutritional searches, Microsoft's Bing now uses Wolfram results.